idiopathic membranous nephropathy
Conditions
Interventions
Sponsors
The First Affiliated Hospital, Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years; 2. Renal biopsy showed that the number of glomeruli was more than 10, and the pathological diagnosis was membranous nephropathy; 3. Baseline 24-hour urine protein quantity >= 3.5G, EGFR (CKD-EPI formula) >= 30ml / min / 1.73m2; 4. Sign informed consent.
Exclusion criteria
Exclusion criteria: 1. There are secondary factors of membranous nephropathy, such as systemic autoimmune disease, infection, tumor and so on; 2. There are contraindications of rituximab use, such as neutrophil < 1.5 * 10^9 / L, platelet < 75 * 10^9 / L, active infection, etc.; 3. Diagnosed as type 1 or type 2 diabetes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24 hours urinary protein quantitative >= 3.5G and serum albumin > 35g / L; | — |
Secondary
| Measure | Time frame |
|---|---|
| 24-hour proteinuria 0.3g-3.5g or at least 50% lower than baseline) or recurrence (progression of proteinuria after complete or partial remission, 24-hour proteinuria >= 3.5G); | — |
Countries
China
Contacts
Public ContactQinghua Liu
The First Affiliated Hospital, Sun Yat-Sen University
Outcome results
None listed