sepsis
Conditions
Interventions
Experimental group:Fluid resuscitation was performed with Bicarbonated ringer's injection
Control group:Fluid resuscitation was performed with normal saline
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Aged 18 years and above; (2) Infected or suspected infected patients; (3) concentration of Lactate >=3mmol/L, rapid fluid resuscitation was needed judged by clinicians; (4) SOFA score or qSOFA score >=2; (5) The patient or his/her guardian agrees and signs the informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients with hypermagnesemia or hypothyroidism; (2) the concentration of serum sodium >160mmol/L or <125mmol/L; (3) Patients with cirrhosis; (4) Patients in need of dialysis (5) Patients complicated with severe active bleeding and in need of massive blood transfusion; (6) women who are pregnant or breastfeeding; (7) in the terminal stage of illness or palliative care; (8) Patients who do not cooperate with comprehensive treatment; (9) Other conditions not considered by the researchers to be consistent with inclusion.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Lactate;concentration of HCO3-;Blood gas analysis;Urine output;Resuscitation fluid volume;Total liquid intake;Total liquid output; | — |
Primary
| Measure | Time frame |
|---|---|
| Lactate clearance rate; | — |
Countries
China
Contacts
Public ContactTongwen Sun
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed