Obstructive sleep apnea syndrome in pregnancy
Conditions
Interventions
Cases group vs normal control group:no
Sponsors
Beijing Obstetrics and Gynecology Hospital, Capital Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Healthy women who were admitted to the obstetrics clinic of our hospital from July 01, 2020 to December 31, 2021 were selected as the object of study. In addition, pregnant women who were diagnosed as OSA by polysomnography (Polysomnography,PSG) before pregnancy and had no other complications were included in the study. "Berlinquestionnaire" was used to assess the risk of OSA in the first trimester of pregnancy. After informed consent, pregnant women with high risk of OSA were selected for sleep breathing monitoring and clinical diagnosis of OSA. The total sample size was calculated in 835 cases. 1) OSA group: 66 pregnant women with high risk of OSA based on the Berlin questionnaire and diagnosed as OSA by PSG. 2) non-OSA group: 132 pregnant women with low risk of OSA base on the Berlin questionnaire or high risk but excluded from OSA by PSG.
Exclusion criteria
Exclusion criteria: Women with chronic hypertension, type 2 diabetes, cardiovascular and cerebrovascular diseases, abnormal thyroid function, liver and kidney diseases, autoimmune system diseases, metabolic diseases, infectious diseases and acute and chronic infectious diseases were excluded. If the following occurs, the subjects will be removed and the corresponding number of subjects will be added: those who do not agree to PSG; those who automatically withdraw from the study or who are unable to follow up the pregnancy outcomes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| adverse pregnancy outcomes; | — |
Countries
China
Contacts
Public ContactWei Song
Beijing Obstetrics and Gynecology Hospital, Capital Medical University
Outcome results
None listed