ICU acquired weakness
Conditions
Interventions
control:total integrate protein formula without dietary fiber
Experimental group:total integrate protein formula plus 24g DF
Sponsors
The General Hospital of Western Command Theater of PLA
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Patients in surgical ICU with craniocerebral trauma, cerebral hemorrhage, organ surgery, limb and spinal surgery were the first choice; (2) Aged between 18 and 65 years old; (3) the 24-hour NUTRIC score was greater than or equal to 5 points, APACHE II score was greater than 10 points; (4) voluntary participation in this study.
Exclusion criteria
Exclusion criteria: (1) There are various bone metabolism or muscle diseases, such as myasthenia gravis; (2) NUTRIC score less than 5; (3) expected ICU stay less than 7 days; (4) accompanied by tumor or type I diabetes, ckd 4-5 of basic diseases, with severe liver disease; (5) family members of patients refused to participate in the study; (6) patients who could not receive enteral nutrition supplements; (7) accompanied by intestinal diseases or factors affecting digestion, absorption, metabolism or excretion; (8) accompanied by thyroid dysfunction or endocrine and metabolic diseases; (9) pregnant or lactating women; (10) history of mental illness; (11) previous history of allergy to drugs known to be used; (12) previous diarrhea, constipation, or intestinal inflammation; (13) top two in the group Weeks of use of antibiotics, probiotics, prebiotics, synbiotics preparations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| average blood glucose level;IGF-1;myostatin; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intestinal flora (Bifidobacterium / Enterobacter Kobe value);albumin;pre-albumin;Globulin;Retinol binding protein;Transferrin;blood creatinine;urea nitrogen;endogenocreatinine clearance rate;ALT;AST;CRP;IL-1;IL-6;TNF-alpha; | — |
Countries
China
Contacts
Public ContactFu-xiang Li, Ning Lin
The General Hospital of Western Command Theater of PLA
Outcome results
None listed