Hepatic ischemia reperfusion injury
Conditions
Interventions
Experimental group:Dexmedetomidine preconditioning during pure laparoscopic donor hepatectomy
Control group:Normal saline preconditioning during pure laparoscopic donor hepatectomy
Sponsors
Beijing Friendship Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
No minimum to 12 Years
Inclusion criteria
Inclusion criteria: 1. Aged younger than 12 years of age; 2. Left lateral lobe grafts procured from living-related donors following pure laparoscopic donor hepatectomy; 3. liver grafts preserved with Celsior solution and implanted using the modified piggy-back technique; 4. Without severe cardiac, pulmonary, kidney and cerebral diseases.
Exclusion criteria
Exclusion criteria: 1. Severe congenital heart diseases accompanied with cardiac?insufficiency or pulmonary hypertension; 2. Stage III or IV encephalopathy; 3. Severe cardiopulmonary disease, such as hepatopulmonary?syndrome (PaO2133 umol/L); 4. Requiring preoperative vasopressor or mechanical ventilation support; 5. Synchronously meet the exclusion criteria of the one-to-one matched donor.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative liver transaminases levellevels;the severity of hepatic ischemia-reperfusion injury; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative hemodynamic parameters;Other postoperative liver function indicators;postoperative kidney function;Intraoperative dosage of vasopressors;Histopathological assessments;Intraoperative serum inflammatory cytokines and oxidative stress indicators;Duration of mechanical ventilation, and intensive care unit and hospital stay;Postoperative complications; | — |
Countries
China
Contacts
Public ContactFu-Shan Xue
Capital Medical University affiliated Beijing Friendship Hospital
Outcome results
None listed