Malignant tumor
Conditions
Interventions
Group A:standard administration of fosapitam and/or olanzapine
Group B:Delaied administration of fosapitam and/or olanzapine
Sponsors
Ordos Central Hospital,Inner Mongolia
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. aged >=18 years old, pathologically diagnosed malignant tumor to accept cisplatin regimen 25mg/m^2/day chemotherapy; 2. KPS score>=70; 3. Before chemotherapy, liver and kidney function, blood routine, electrocardiogram are normal.Blood tests must meet the requirements of white blood cells > 3.5 * 10^9, neutrophils > 1.5 *10^9, platelets > 85 *10^9, alkaline phosphatase less than 2.5 times of normal value, glutamic pyruvic transaminase 2.5 times of normal value, bilirubin 1.5 times of normal value, and creatinine 1.5 times of normal value; 4. CT and (MRI) evaluated the tumor site without chemotherapy contraindications; 5. Obtain the patient's informed consent and sign the consent form.
Exclusion criteria
Exclusion criteria: 1. Primary exclusion criteria were: patients who were unable to take oral drugs and had a long history of hormone use; 2. Those who received radiotherapy at the same time and those who had vomiting 24 hours before chemotherapy; 3. Symptomatic primary or metastatic central nervous system metastasis and and patients who have received brain radiotherapy; 4. Pregnant or breast-feeding; 5. Concurrent quinolone antibiotic therapy; 6. Partial/complete bowel obstruction; 7. Known hypersensitivity to 5-HT3 receptor; 8. Aprepitant, and olanzapine; 9. Treatment with illegal drugs or evidence of alcohol abuse; 10. Patients with gastrointestinal tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| overall phase total contral; | — |
Secondary
| Measure | Time frame |
|---|---|
| overall phase complete response;overall phase total protection;FILE scale;Malignant score;Side effects; | — |
Countries
China
Contacts
Public ContactLi Quanfu
Ordos Central Hospital, Inner Mongolia, Ordos clinical Medical College, Inner Mongolia Medical University
Outcome results
None listed