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Pharmacokinetic/pharmacodynamic of voriconazole in body fluids of critically ill patients

Pharmacokinetic/pharmacodynamic of voriconazole in body fluids of critically ill patients

Status
Recruiting
Phases
Phase 4
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000040672
Enrollment
Unknown
Registered
2020-12-08
Start date
2020-12-01
Completion date
Unknown
Last updated
2021-03-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fungal infections

Interventions

Peritoneal cavity group:Routine voriconazole treatment
Pleural cavity group:Routine voriconazole treatment
Pericardial cavity group:Routine voriconazole treatment
Cerebrospinal fluid group :Routine voriconazole treatment
Bile group:Routine voriconazole treatment

Sponsors

The First Affiliated Hospital of Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Aged >=18 years; 2. Undergoing drainage of peritoneal fluid or pleural fluid or pericardial fluid or cerebrospinal fluid or bile; 3. Receiving intravenous voriconazole.

Exclusion criteria

Exclusion criteria: 1. Concomitant use of strong CYP450 enzyme inhibitors or inducers; 2. Absence of voriconazole concentrations; 3. Absence of important dosing information or clinical data.

Design outcomes

Primary

MeasureTime frame
Plasma voriconazole concentrations;Voriconazole concentrations in peritoneal fluid;Voriconazole concentrations in pleural fluid;Voriconazole concentrations in pericardial fluid;Voriconazole concentrations in cerebrospinal fluid;Voriconazole concentrations in bile;Clinical efficacy/outcomes;Adverse reaction rate;

Secondary

MeasureTime frame
Biochemical indices;

Countries

China

Contacts

Public ContactCai Changjie

The First Affiliated Hospital of Sun Yat-sen University

caichjie@mail.sysu.edu.cn+86 13570097848

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026