Diatetes
Conditions
Interventions
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Subjects must meet all of the following criteria to be enrolled: patients aged 18 years or older and less than 65 years old, who (1999) diagnostic criteria for type 2 diabetes mellitus, patients with diabetes duration =25kg / m2, HbA1c 7.0% to 9.0%, stable weight (weight fluctuation < 5% in the first three months), signing informed consent and complying with the study protocol.
Exclusion criteria
Exclusion criteria: Subjects were excluded from the study if any of the following exclusion criteria were met. Diabetes mellitus other than type 2 diabetes mellitus clinically diagnosed; there were acute metabolic complications within 6 months before screening, including lactate acidosis, nonketotic hyperosmolar coma and diabetic ketoacidosis; those with severe acute and chronic complications of diabetes mellitus (such as myocardial infarction, cerebrovascular accident, congestive heart failure, blindness caused by diabetic retinopathy, renal failure and Severe foot ulcer, etc. Patients with endocrine diseases other than type 2 diabetes mellitus who are under treatment and not under control; hypoglycemia patients who are easy to relapse according to researchers' judgment; drugs affecting body weight (such as orlistat, glucocorticoid, etc.) or drugs affecting appetite and gastrointestinal motility in recent 3 months; severe liver function injury (ALT >=3 ULN); severe renal insufficiency (EGFR 70 g/week); Patients with mental disorders, unable to cooperate with the test, unable to eat by mouth, patients with gastrointestinal surgery history, patients with intolerance or allergy to the ingredients of meal replacers, allergic to metformin and engelgelin, pregnant and lactating women, tumor history within 5 years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| glycosylated hemoglobin; | — |
Countries
China
Contacts
Public ContactLixin Guo
Department of Endocrinology, Beijing Hospital
Outcome results
None listed