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Clinical study on the effect of repetitive transcranial magnetic stimulation on the function of motor neurons in the anterior spinal horn of hemiplegic patients with stroke

Clinical study on the effect of repetitive transcranial magnetic stimulation on the function of motor neurons in the anterior spinal horn of hemiplegic patients with stroke

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000040642
Enrollment
Unknown
Registered
2020-12-05
Start date
2020-12-15
Completion date
Unknown
Last updated
2021-03-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Interventions

Control group:Routine rehabilitation
Experimental group 1:Routine rehabilitation + low frequency rTMS treatment
Experimental group 2:Routine rehabilitation+ high frequency rTMS treatment

Sponsors

Zhongda Hospital Affiliated to Southeast University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. The first onset of cerebral infarction or cerebral hemorrhage, the focus is on one cerebral hemisphere; 2. Various degrees of motor dysfunction in unilateral limbs; 3. Stable vital signs, clear consciousness, and no severe cognitive impairment; 4. No swelling and skin damage in upper limbs; 5. The course of illness is 0-6 months; 6. Aged 18-80 years old, men and women; 7. Voluntarily participate and sign an informed consent form.

Exclusion criteria

Exclusion criteria: 1. Unstable or uncooperative; 2. Large area of cerebral infarction; 3. Combined with other central nervous system damage other than stroke; 4. Combined with neuromuscular junction disease, peripheral neuropathy, radiculopathy or motor neuron disease; 5. Have used drugs that affect muscle tension; 6. Have upper limb motor dysfunction due to past trauma, osteoarthropathy, etc.; 7. Patients with metal or electronic equipment at the stimulation site; 8. Patients with a history of epilepsy or risk of seizures; The patient refused to continue for various reasons and asked to withdraw from the experiment.

Design outcomes

Primary

MeasureTime frame
F wave;motor unit number estimation,MUNE;motor-evoked potentials, MEP;modified Ashworth scale, MAS;Fugl-Meyer Assessment, FMA;

Countries

China

Contacts

Public ContactWang Hongxing

Zhongda Hospital North Campus

wang_hongxing@163.com+86 13770823776

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026