Henoch-Schonlein purpura nephritis
Conditions
Interventions
A:Basic treatment + hydroxychloroquine (5mg/kg.d, taken orally in 2 doses)
B:Basic treatment
Sponsors
Shengjing Hospital of China Medical University
Eligibility
Sex/Gender
All
Age
3 Years to 14 Years
Inclusion criteria
Inclusion criteria: 1. Aged 3 to 14 years; 2. Inpatients in Shengjing Hospital; 3. In line with 2016 evidence-based guidelines for diagnosis and Treatment of Purpura nephritis, the diagnosis was purpura nephritis.
Exclusion criteria
Exclusion criteria: 1. Patients with nephrotic syndrome type and rapid deterioration of renal function requiring immunosuppressive therapy other than glucocorticoids; 2. Allergic to hydroxychloroquine; 3. Abnormal visual field; 4. Participate in other drug trials within the month; 5. Other conditions in which the investigator considers it inappropriate to participate in the clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage decrease in urinary protein from baseline;The time of urine protein turn negative;The time of urine red blood cells turn normal; | — |
Secondary
| Measure | Time frame |
|---|---|
| The percentage of urinary protein decreased from baseline at 2 months and 4 months of treatment;Percentage change in GFR at 6 months of treatment;Glucocorticoid accumulation per kg body weight for 6 months of treatment;Recurrence of rash;Improvement of joint symptoms;Improvement of digestive system symptoms;Glucocorticoid adverse reactions; | — |
Countries
China
Contacts
Public ContactWang Xiuli
Shengjing Hospital of China Medical University
Outcome results
None listed