ICU acquired weakness
Conditions
Interventions
control:enteral formula with integrate protein
intervention group:enteral formula with integrate protein plus protein-peptide module
Sponsors
The General Hospital of Western Command Theater of PLA
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Patients in surgical ICU with craniocerebral trauma, cerebral hemorrhage, organ surgery, limb and spinal surgery were the first choice; (2) Aged between 18 and 65 years old; (3) the 24-hour NUTRIC score was greater than or equal to 5 points, APACHE II score was greater than 10 points; (4) voluntary participation in this study.
Exclusion criteria
Exclusion criteria: (1) There are various bone metabolism or muscle diseases, such as myasthenia gravis; (2) NUTRIC score less than 5; (3) expected ICU stay less than 7 days; (4) accompanied by tumor or type I diabetes, ckd4-5 of basic diseases, with severe liver disease; (5) family members of patients refused to participate in the study; (6) patients who could not receive enteral nutrition supplements; (7) accompanied by intestinal diseases or factors affecting digestion, absorption, metabolism or excretion; (8) accompanied by thyroid dysfunction or endocrine and metabolic diseases; (9) pregnant or lactating women; (10) history of mental illness; (11) previous history of allergy to drugs known to be used; (12) acute and chronic liver diseases; (13) acute and chronic intestinal diseases, such as inflammatory bowel disease Enteritis, intestinal infection, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pre-albumin;IGF-1;myostatin; | — |
Secondary
| Measure | Time frame |
|---|---|
| Globulin;albumin;total protein;Retinol binding protein;transferrin;serum creatinine;urea;Endogenous creatinine clearance rate;ALT;AST;total bilirubin;CRP;IL-6;TNF-a;IL-1; | — |
Countries
China
Contacts
Public ContactFu-xiang Li, Ning Lin
The General Hospital of Western Command Theater of PLA
Outcome results
None listed