non small cell lung cancer
Conditions
Interventions
A:the sedative of induction and anesthesia maintenance is sevofluane
B:the sedative of induction and anesthesia maintenance is propofol
D:Paravertebral block pre-operation
Sponsors
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients who volunteered to participate in the study and signed written informed consent; 2) Patients aged 18 to 60 years at the time of signing the informed consent; 3) Planned radical resection of lung cancer under general anesthesia; 4) the American society of anesthesiologists I or II.
Exclusion criteria
Exclusion criteria: 1) Patients with a history of malignant tumor; 2) Patients who received preoperative chemotherapy or radiotherapy; 3) Patients with recent infection or taking immunosuppressive drugs; 4) BMI31; 5) Combined with hepatic and renal insufficiency, respiratory insufficiency, and cardiac insufficiency; 6) Contraindications for the use of drugs in the study; 7) Contraindications for paravertebral block, including severe coagulation dysfunction, puncture site infection, trauma or spinal surgery history; 8) Long-term drinking, long-term use of sedative drugs or antidepressants and other psychotropic drugs; 9) Patients who have participated in other pharmaceutical studies in the past month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NRF2;NLRP3;ROS;GSH;IL-11; | — |
Countries
China
Contacts
Public ContactLily Sun
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Outcome results
None listed