ESRD-peritoneal dialysis
Conditions
Interventions
Experimental group:Beraprost sodium 20ug tid
Control group:No
Sponsors
Tongji Hospital, Tongji Medical Colloge Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years; 2. On peritoneal dialysis due to end stage renal disease; 3. Residual renal function greater than 2ml/min/1.73m2 at the beginning of dialysis; 4. No coagulation disorders, history or risk factors for upper gastric tract bleeding, hemoptysis, hemorrhagic stroke; 5. No application of anticoagulants, antiplatelet drugs and thrombolytics currently and during the 6 months before the trial; 6. Have no use of ACEI/ARB drugs for at least 6 months, and ACEI/ARB drugs are not expected to be used during the study.
Exclusion criteria
Exclusion criteria: 1. Have no congestive heart failure, COPD, myocardial infarction, liver cirrhosis, active malignant neoplasm or other severe primary diseases; 2. Poor compliance and difficult to cooperate with doctors and researchers; 3. Have psychological problems, alcohol or drug dependence; 4. Have malignant hypertension or poor control of blood pressure; 5. Unable to perform peritoneal dialysis for any reasons such as abdominal surgery or intestinal adhesion; 6. Have renal transplant or hemodialysis history; 7. Currently participate in other clinical research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Decline rate of residual renal function;Time to anuria;Mortality rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence rate of cardiovascular events;Hospitalization rate;Peritonitis rate;Rate of technique failure of PD;Target blood pressure achievement rate; | — |
Countries
China
Contacts
Public ContactYao Ying
Tongji Hospital, Tongji Medical Colloge Huazhong University of Science and Technology
Outcome results
None listed