primary biliary cholangitis
Conditions
Interventions
Gold Standard:PBC can be diagnosed by meeting 2 of the following 3 criteria :(1) serum biochemical indication of increased ALP
(2) When AMA is positive or AMA is negative, other PBC specific autoantibodies, such as SP100 and GP210 are positive
(3) Histological evidence suggested non-suppurative destructive cholangitis and inter-lobu
Index test:AMA 
in 
serum 
of 
PBC 
was 
by 
AMA-M2 
test 
and 
BPO 
test, 
Sponsors
The Second Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Suspected case of PBC: 1. Middle-aged women, the main clinical manifestations of fatigue, skin itching, jaundice, osteoporosis, may be accompanied by a variety of autoimmune diseases; 2. An increase in ALP and/or GGT of unknown etiology; 3. Exclusion of other causes of clear liver disease, such as: drug liver injury, hepatitis B, hepatitis C, obstructive liver injury, etc.
Exclusion criteria
Exclusion criteria: 1. Autoimmune hepatitis; 2. Primary sclerosing cholangitis; 3. Viral hepatitis; 4. Genetic metabolic diseases such as hepatolaneus disease; 5. Alcoholic liver disease; 6. Nonalcoholic fatty liver disease; 7. Space-occupying lesions of the liver, gallbladder, spleen and other organs; 8. Other diseases associated with enlarged liver and spleen: severe cardiopulmonary diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| For the included PBC patients, both traditional AMA-M2 test and BPO test were used for detection, and UK-PBC risk score was performed for PBC patients; | — |
Countries
China
Contacts
Public ContactTang Yingmei
The Second Affiliated Hospital of Kunming Medical University
Outcome results
None listed