Study on the effect of esketamine on single-pore video-assisted pulmonary surgery under laryngeal mask airway (LMA) preserving spontaneous respiratory anesthesia

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000040584

Enrollment

Unknown

Registered

2020-12-03

Start date

2021-01-01

Completion date

Unknown

Last updated

2021-03-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia plan for pulmonary surgery under single - hole thoracoscope

Interventions

Experimental group:esketamine

Control group:Physiological saline

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 to 65 years, BMI 18-25kg/m2; 2. ASA I to II; 3. It is planned to perform single-hole thoracoscopic pulmonary surgery under spontaneous respiratory and laryngeal mask airway anesthesia. The surgical types include: pneumothorax, hand hyperhidrosis, wedge resection of the lung, segmental resection of the lung and other relatively simple operations.

Exclusion criteria

Exclusion criteria: 1. History of allergy or contraindications to ropivacaine hydrochloride, esketamine, dexmedetomidine (serious risk of increased blood pressure and intracranial pressure, poorly controlled or untreated hypertension, untreated or undertreated hyperthyroidism, gastrointestinal bleeding); 2. Mental illness and other chronic pain or other conditions that may confuse analgesic response 3. Unable to read and write Chinese, communication barrier; 4. Emergency surgery or trauma patients; 5. Previous intraoperative knowledge; 6. Patients who is admitted to ICU after operation; 7. Patients with alcohol or drug dependence or a history of drug abuse; 8. Patients who refuse to attend.

Design outcomes

Primary

Measure	Time frame
The opioid dosage during the perioperative period, as well as the times and frequency of postoperative analgesia pump pressure;Hemodynamics and arterial blood gas changes;	—

Secondary

Measure	Time frame
Scores of acute pain at 12h, 24h and 48h after operation;Scores of mental state at 24h and 48h after operation;Scores of depression at 24h and 48h after operation;Chronic pain at 1, 3, 6 and 12 months after the operation;Changes of inflammatory factors (IL12, IL-6, TNF-alpha) at 12h, 24h, 48h after surgery;	—

Countries

China

Contacts

Public ContactYang Jianjun, Fu Zhijie

The First Affiliated Hospital of Zhengzhou University

13676964593@163.com+86 13676964593

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026