Clinical changes in the contralateral unaffected eyes of patients with unilateral infectious keratitis: An in vivo confocal microscopy study

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2000040565

Enrollment

Unknown

Registered

2020-12-02

Start date

2020-12-01

Completion date

Unknown

Last updated

2021-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infectious keratitis

Interventions

Case series:No

Eligibility

Sex/Gender

All

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: We performed a prospective, cross-sectional, controlled, single-blinded study. Thirty eyes of 30 normal volunteers constituted the control group after being screened and ruled out for dry eye disease or any other corneal pathology.Ninety patients with diagnosis of unilateral VK,BK and FK with ocular involvement were recruited between 2018 and 2019 from the Eye Hospital, the First Affiliated Hospital of Harbin Medical University, Harbin, China.

Exclusion criteria

Exclusion criteria: Subjects with a history of infectious keratitis, ocular inflammatory disease, ocular trauma, ocular surgery, contact lens use, diabetes, systemic neuropathies or immunosuppression were excluded

Design outcomes

Primary

Measure	Time frame
Corneal epithelial cells ;Dendritic cells;Corneal endothelial cells;Density of corneal nerve;	—

Countries

China

Contacts

Public ContactHong Zhang

First Ward in Department of Ophthalmology, the First Affiliated Hospital of Harbin Medical University

18846081489@163.com+86 0451 85553951

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026