pelvic recurrent cervical carcinoma
Conditions
Interventions
Arm 1:radioactive iodine 125 seed implantation with CTV from GTV+3mm
Arm 2:radioactive iodine 125 seed implantation with CTV from GTV+6mm
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Confirmed by pathology; (2) There are lesions that can be evaluated by imaging, and the largest tumor diameter is =1cm and =7cm; (3) Those who have received external radiotherapy in the past and are not suitable for re-external radiotherapy or who refuse to re-external radiotherapy; (4) Not suitable for surgery or refuse surgery; (5) Age = 18 years old; (6) KPS=60 points; (7) Sufficient blood reserve: white blood cell count =3×109/ml; granulocyte count =1.5×109/ml; hemoglobin =90g/L; platelet >50×109/L; (8) Good liver function: serum total bilirubin concentration=1.5×ULN; ALT or AST=3×ULN; (9) Good renal function: serum creatinine value=1.5×ULN, urine protein 3 months;
Exclusion criteria
Exclusion criteria: (1) Cannot tolerate anesthesia; (2) Cannot tolerate puncture; (3) There is no suitable puncture path; (4) The preoperative plan design cannot meet the clinical treatment requirements; (5) Those with serious bleeding tendency, such as platelets 18s, prothrombin activity <40%, and anticoagulation therapy and/or antiplatelet aggregation drugs in seed implantation therapy Stopped before <1 week; (6) Skin ulcers caused by tumors; (7) There are serious complications (such as severe hypertension, diabetes, etc.) that lead to clinical risks; (8) Patients with active infectious diseases, severe trauma and stroke; (9) People with mental disorders; (10) Pregnant or lactating women; (11) Patients who are allergic to iodine contrast agents.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Local control time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Dosimetry;Objective response rate;Disease control rate;Pain relief rate;Treatment-related toxicity;Overall survival;Quality of life; | — |
Countries
China
Contacts
Public ContactWang Junjie
Peking University Third Hospital
Outcome results
None listed