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Water-soluble tomato extract improves platelet function in subjects with metabolic syndrome: a randomized clinical trial

Dose-response effects of water-soluble tomato extract on platelet function in subjects with metabolic syndrome: a randomized clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000040559
Enrollment
Unknown
Registered
2020-12-02
Start date
2021-01-01
Completion date
Unknown
Last updated
2021-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

metabolic syndrome

Interventions

placebo group:take orally 600 mg placebo per day
150mg / d water-soluble tomato extract intervention group:take orally 600 mg drug per day (contains 150mg water-soluble tomato extract)
150mg / d water-soluble tomato extract intervention group:take orally 600 mg drug per day (contains 300mg water-soluble tomato extract)

Sponsors

School of Public Health (Shenzhen), Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
35 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1) Aged 35-70 years old; 2) According to the diagnostic criteria of metabolic syndrome in the "Chinese Type 2 Diabetes Prevention Guidelines 2017", and three or more of following are acceptable: (1) Abdominal obesity (central obesity): waist circumference >=90 cm for men and >=85cm for women; (2) Hyperglycemia: fasting blood glucose >=6.1mmol/L or 2h after glucose load >=7.8mmol/L; (3) Hypertension: systolic blood pressure >=130mmHg and (or) diastolic blood pressure >=85mmHg; (4) Fasting TG>=1.70mmol/L; (5) Fasting HDL-C<1.04mmol/L; 3) Sign informed consent and insist on participating in the research.

Exclusion criteria

Exclusion criteria: 1) Antihypertensive drugs, lipid-lowering drugs, hypoglycemic drugs or insulin therapy was used in recently six months; 2) Take drugs/dietary supplements, such as aspirin, fish oil and etc., that affect platelet function in recently two months; 3) blood system disease or infection; 4) Blood pressure >=160/100mmHg; 5) Low platelet count (whole blood platelet<100 x 10^9/mL); 6) Abnormal hemoglobin (male <120g/L, female <110g/L); 7) Low hematocrit (male <40%, female <37%); 8) Prothrombin time (PT) is outside the normal reference range; 9) Pregnant women or nursing mothers; 10) Abnormal menstrual cycle, taking birth control pills or hormone replacement therapy; 11) Gastric ulcer, liver or kidney dysfunction; 12) Allergic to tomatoes or its ingredients.

Design outcomes

Primary

MeasureTime frame
platelet aggregation and acativation;Platelet granule release;—

Secondary

MeasureTime frame
Coagulation function;Blood pressure;Blood sugar;Blood fat;—

Countries

China

Contacts

Public ContactYan Yang

School of Public Health (Shenzhen), Sun Yat-sen University

yangyan3@mail.sysu.edu.cn+86 20 87330687

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026