none
Conditions
Interventions
A: High Dose Milk Drinking Group:500ml (55g milk powder) of liquid milk daily
A: Low-dose milk group:300ml (33g milk powder) of liquid milk daily
B: Low dose control group:Daily syrup (45g sugar)
B: High-dose control group:Daily syrup (108g sugar)
B: Low dose milk drinking group:250ml of liquid milk daily
B: High dose milk drinking group:600ml of liquid milk daily
Sponsors
Nanjing Medical University School of Public Health
Eligibility
Sex/Gender
All
Age
7 Years to 30 Years
Inclusion criteria
Inclusion criteria: Female: 1. 22-26 years old; 2. Normal weight with a BMI between 18.5 and 23.9; 3. Regular menstrual cycle, with a stable menstrual cycle of 28-32 days for six months; 4. Have not recently taken oral contraceptives, or other hormonal drugs; 5. No significant experience with lactose intolerance. Children: 1. The age range is 7 to 9 years old; 2. Half male and half female, half normal weight and half obese children; 3. No history of milk allergy; 4. No or mild lactose intolerance; 5. Be able to drink the prescribed amount of milk (up to 1000ml+) in 10 minutes; 6. With the consent of parents and children, they are willing to participate in the experiment.
Exclusion criteria
Exclusion criteria: Female: 1. Females with diseases that may interfere with the results of the experiment, such as estrogen-related diseases such as ovarian cysts, uterine fibroids, cervical cancer, breast cancer, lobular hyperplasia, endometrial cancer, endometriosis, polycystic ovary syndrome, etc., after a physical examination; 2. Not be able to cooperate with various experimental arrangements. Children: 1. Children diagnosed with clinical precocious puberty; 2. Children with major diseases such as leukemia, diabetes, heart disease, etc.; 3. Failure to comply with the experimental protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Free Estradiol;Free Progesterone;Testosterone;Luteinizing Hormone;Follicle stimulating hormone;Prolactin;Conjugated Estradiol;Conjugated Progesterone; | — |
Countries
China
Contacts
Public ContactZhixu Wang
Nanjing Medical University School of Public Health
Outcome results
None listed