biliary atresia
Conditions
Interventions
Preoperative intervention group:N-Acetylcysteine
Postoperative intervention group:N-Acetylcysteine
Preoperative control group:Conventional therapy
postoperative control group:Conventional therapy
Sponsors
Guangzhou Women and Children Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Less than or equal to 90 days of the age at time of Kasai Portoenterostomy; 2. Children diagnosed as biliary atresia by Symptoms and signs and preoperative examination (B-ultrasound, liver function) and Cholangiography; 3. The legal guardian signs a consent form after understanding the risks and nature of the research.
Exclusion criteria
Exclusion criteria: 1. Decompensated liver disease (INR >1.3) despite parenteral Vitamin K administration); 2. Active respiratory infections; 3. Renal insufficiency; 4. There are serious complication, such as congenital or acquired lung diseases, neurological diseases, cardiovascular diseases, metabolic diseases, endocrine diseases and kidney diseases, which may interfere with the progress and results of the research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Liver function index;Blood routine;CD177 cell number;ROS production in CD177 cells;Expression of mitochondria and membrane potential in CD177 cells;Detection of neutrophil extracellular traps in CD177 cells;Detection of neutrophil extracellular traps in plasma;Detection of inflammatory factors in plasma;mRNA sequencing of CD177 cells; | — |
Countries
China
Contacts
Public ContactZHANG RUIZHONG
Guangzhou Women and Children Medical Center
Outcome results
None listed