amnestic mild cognitive impairment
Conditions
Interventions
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: All the patients were right-handed, and over 55 years old, complained of memory loss, without objective evidence of memory decline. The cognitive function was not affected, the ability of daily living was normal, and there was no dementia. The score of dementia memory was at least 0.5. Mini Mental State Examination (MMSE). The scores of MMSE ranged from 24 to 30, and MOCA score 18-26; Coronal T1 weighted MR images showed medial temporal lobe atrophy with visual score greater than grade 1 (choroidal fissure enlargement only) or grade 2 (with enlargement of temporal horn of lateral ventricle), fluid attenuated inversion recovery (FLAIR) images showed white matter with a lesion rating of less than 2 (with high signal spots or patchy fusion). All the patients were right-handed, they voluntarily participated in the study and signed informed consent.
Exclusion criteria
Exclusion criteria: cognitive impairment caused by other known causes (such as stroke, craniocerebral injury, alcohol dependence, epilepsy, depression, Parkinson's disease or other neurological or mental diseases), Suffering from other serious diseases, severe visual or hearing impairment, with MRI contraindications (such as cardiac pacemaker and metal implantation in vivo), failure to complete neuropsychological scale assessment, MRI examination or unqualified image quality, failed to complete follow-up examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| psychological scale;MRI;18 F-FDG examination; | — |
Countries
China
Contacts
Public ContactKuncheng Li
Xuanwu Hospital, Capital Medical University
Outcome results
None listed