Digestive tract disease
Conditions
Interventions
Esketamine group:Before painless gastroscopy, give esketamine and propofol
Nalbuphine group:Before painless gastroscopy, give nalbuphine and propofol
Sponsors
Shanghai Children's Medical Center
Eligibility
Sex/Gender
All
Age
3 Years to 8 Years
Inclusion criteria
Inclusion criteria: 1. Aged 3~8 years old; 2. Due to dyspepsia, gastric ulcer, or other diseases (such as varicose veins, ingestion of foreign bodies and corrosive esophagitis, etc.) need to undergo upper gastrointestinal endoscopy; 3. ASA score I or II.
Exclusion criteria
Exclusion criteria: 1. Patients with contraindications to general anesthesia; 2. Children with a history of abnormal recovery after anesthesia; 3. Patients who are tolerant or allergic to esketamine hydrochloride, propofol, and nalbuphine; 4. have used anesthesia within 24 hours Patients who have taken analgesics or have used anesthetics within 5 days, who have taken analgesics, sedatives or anticonvulsants for a long time (continuously or intermittently); 5. Children who are given medication before anesthesia; 6. Pre-existing Abnormal coagulation function, bleeding tendency (such as active peptic ulcer) or undergoing thrombolytic or anticoagulant therapy, anemia or thrombocytopenia; 7. Abnormal liver and kidney function or history of liver or kidney disease; 8. Researchers consider it inappropriate for patients to participate; 9. The child or parents refuse to take part in.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| drug dose; | — |
Countries
China
Contacts
Public ContactYing Sun
Department of Anesthesiology, Shanghai Children's Medical Center
Outcome results
None listed