Pemphigus
Conditions
Interventions
Relapse group:glucocorticoids and/or immunosuppressant
Sponsors
Department of Dermatology, the Second Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Aged >=18 years; (2) Clinical features suggestive of pemphigus vulgaris or pemphigus foliaceus; a histological image of intraepidermal acantholysis; and deposition of IgG, complement component 3, or both on the keratinocyte membrane detected by direct immunofluorescence; (3) A person who is diagnosed for the first time or whose disease is in the stage of disease control or consolidation and maintenance treatment. Disease control was defined as the cessation of new lesion formation and onset of healing of established lesions. Consolidation and maintenance treatment: There is no new blisters for at least 2 weeks, and 80% of the existing skin lesions have healed, and glucocorticoids begin to decrease at this time.
Exclusion criteria
Exclusion criteria: (1) At the same time suffering from other diseases that need long-term maintenance treatment with glucocorticoids; (2) Pregnancy; (3) Patients with tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients with relapse; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to relapse;Serum immunoglobulin;Histological and/or direct immunofluorescence;Proportion of patients achieving disease control;the quality of life;Depression score;Anxiety score; | — |
Countries
China
Contacts
Public ContactXiaolan Li
Department of Dermatology, the Second Affiliated Hospital of Kunming Medical University
Outcome results
None listed