diseases of upper digestive tract
Conditions
Interventions
Conventional bismuth quadruple therapy group:Rabeprazole + amoxicillin + clarithromycin + bismuth
High-dose dual therapy group:Rabeprazole + amoxicillin
Based on resistance gene therapy group:Rabeprazole + 2 sensitive antibiotics
Sponsors
Affiliated Hospital of Yangzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Aged 18-70 years, male or female; (2) He presented with discomfort symptoms such as abdominal pain, abdominal distension, acid reflux, belching, nausea, vomiting, hematemesis, and melena; (3) Positive 14C breath test; (4) No previous H. pylori eradication therapy; (5) Patients who have not used antibiotics, bismuth, H2 receptor antagonists and PPI preparations; (6) Agree to gastroscopy to take gastric mucosal biopsy tissue samples for Helicobacter pylori resistance gene detection; (7) Agree to Helicobacter pylori eradication therapy, and willing to cooperate with the doctor for follow-up investigation of eradication efficacy; (8) Signed informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients with a history of esophageal and gastrointestinal surgery; (2) Patients with bleeding, perforation, pyloric obstruction, and cancer complications; (3) Pregnant or lactating women; (4) Patients who cannot avoid alcohol consumption during the trial; (5) Patients with severe liver, kidney, heart, brain, lung, endocrine system, hematopoietic system diseases or other serious diseases that affect the evaluation of this study; (6) Patients with malignant tumors; (7) Patients can not correctly express their complaints, such as psychosis, severe neurosis; (8) Patients who are allergic to the drugs used in this study; (9) Various factors that are difficult to complete follow-up or affect compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| eradication of Helicobacter pylori;Incidence of adverse reactions;Improvement of gastrointestinal symptoms; | — |
Countries
China
Contacts
Public ContactYanbing Ding
Affiliated Hospital of Yangzhou University
Outcome results
None listed