acute ischemic stroke
Conditions
Interventions
Group 1:Probucol combined with atorvastatin
Group 2:Atorvastatin therapy
Sponsors
Affiliated Hospital of Chengde Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. The patient is first onset (or previous history of cerebral infarction, TIA, mRS score 0-1 points) was confirmed by head CT or MRI; 2. According to the diagnostic criteria of acute ischemic stroke, it was confirmed as atherosclerotic cerebral infarction; The onset time was within 48h, the onset age was less than 80 years old, and the patients did not take lipid-regulating drugs within 1 month; 3. Patients willing to cooperate, good compliance.
Exclusion criteria
Exclusion criteria: 1. Previous history of intracranial space-occupying disease, stroke, intracranial arteritis and hypertensive encephalopathy; 2. Patients with malignant tumors; 3. Severe infection or inflammation, severe liver or kidney dysfunction, severe anemia, and severe coagulation dysfunction; 4. Women during pregnancy and lactation; 5. The patient has received treatment before admission and has taken lipid-regulating drugs within 1 month; 6. Patients with severe dementia or severe mental disorder who unable to complete the detection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum Oxidized low density lipoprotein (OX-LDL);Serum Oxidized low density lipoprotein (OX-LDL);Marixmeralloproteinase-9 (MMP-9);F2-ISoprpstanes;Carotid intima intima thickness;Vulnerable plaque; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intima plaque area; | — |
Countries
China
Contacts
Public ContactYu Ning
Affiliated Hospital of Chengde Medical University
Outcome results
None listed