Periodontitis
Conditions
Interventions
the periodontitis group:Treatment of periodontitis
Sponsors
Peking University of Stomatology
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: The diagnosis of periodontitis was according to the new classification of periodontal diseases and conditions released in 2018, 20 the diagnoses were periodontitis Stage III or IV. Stage I: Interdental CAL at site of greatest loss: 1 to 2 mm; Radiographic bone loss: Coronal third (=5mm; Radiographic bone loss: Extending to mid-third of root and beyond; Tooth loss due to periodontitis of =6 mm, Vertical bone loss >=3 mm, Furcation involvement Class II or III, Moderate ridge defect. Stage IV: Interdental CAL at site of greatest loss: 5mm; Radiographic bone loss: Extending to mid-third of root and beyond; Tooth loss due to periodontitis of >=5 teeth; Need for complex rehabilitation due to: Masticatory dysfunction Secondary occlusal trauma,(tooth mobility degree >=2), Severe ridge defect Bite collapse, drifting, flaring, Less than 20 remaining teeth (10 opposing pairs). Grade A: Evidence of no loss over 5 years, Heavy biofilm deposits with low levels of destruction, non-smoker, normoglycemic/ no diagnosis of diabetes. Grade B: =2 mm over 5 years, Destruction exceeds expectation given biofilm deposits; specific clinical patterns suggestive of periods of rapid progression and/or early onset disease (e.g., molar/incisor pattern; lack of expected response to standard bacterial control therapies), smoker >=10 cigarettes/day, HbA1c >=7.0% in patients with diabetes.
Exclusion criteria
Exclusion criteria: 1. patient 60 years old; 2. Take antibiotics within three months; 3. Pregnant or lactating women; 4. The presence of cardiovascular, endocrine and other systemic diseases; 5. Did not agree to participate in the experiment, did not sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Probing Depth;Clinical Attachment Loss;Bleeding Index;White Blood Cell count;Red Blood Cell count;hemoglobin;Hematocrit;mean corpuscular volume;mean corpuscular hemoglobin;erythrocyte sedimentation rate;Interleukin-6, IL-6;C-reactive protein, CRP;Serum iron;Serum ferritin;Hepcidin;transferrin; | — |
Secondary
| Measure | Time frame |
|---|---|
| total Cholesterol;Triglyceride;High Density Lipoprotein;Low Density Lipoprotein;fasting Glucose;tumor necrosis factor-alpha, TNF-alpha; | — |
Countries
China
Contacts
Public ContactHou Jianxia
Peking University of Stomatology
Outcome results
None listed