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Observational study on the effect of interleukin-39 on the severity and prognosis of sepsis

Observational study on the effect of interleukin-39 on the severity and prognosis of sepsis

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000040443
Enrollment
Unknown
Registered
2020-11-28
Start date
2020-11-20
Completion date
Unknown
Last updated
2021-03-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Interventions

Case series:No

Sponsors

Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 to 90 years old; 2. Diagnosis of sepsis: for patients who meet the new version of sepsis diagnosis, organ dysfunction caused by infection refers to the increase of more than 2 points at the baseline level according to the sequential organ failure assessment (sofa) score (see Table 1); 3. If they are women in childbearing period, they should contraception at least one month before screening, and promise to take contraception during the whole study period and continue to the specified time after the end of the study; 4. Within 72 hours after onset of the disease; 5. All the patients signed the informed consent of the study.

Exclusion criteria

Exclusion criteria: 1. Pregnant or lactating women; 2. More than 72 hours of onset; 3. Severe chronic failure of heart, liver, lung, kidney and blood system existed before admission; 4. Cancer without cure; 5. Autoimmune disease or immunosuppression (previous solid organ or bone marrow transplantation, AIDS, long-term use of immunosuppressants or hormones, etc.); 6. Use of other trial drugs within the time frame of this study.

Design outcomes

Primary

MeasureTime frame
Interleukin 39;Prognosis;—

Secondary

MeasureTime frame
Interleukin 2 receptor;Interleukin 6;Interleukin 8;Interleukin 10;Interleukin 1ß;Tumor necrosis factor-alpha;SOFA score;APACH II score;Blood cell analysis;Blood gas analysis;Liver function index;Renal function index;temperature;heart rate;blood pressure;Coagulation function index;C-reactive protein;Procalcitonin;NT-proBNP;Myocardial protein;Immune function index;Humoral immunity index;Marshall score;days in hospital;Cardiac ultrasound;micro-organism cultur;—

Countries

China

Contacts

Public ContactEnqiang Mao

Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine

maoeq@yeah.net+86 13501747906

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026