Chronic obstructive pulmonary disease
Conditions
Interventions
Sponsors
Northern Jiangsu People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged >=18 years old; 2. Patients diagnosed with COPD and combined with type II respiratory failure and undergoing invasive ventilation; bronchial-pulmonary infections aggravate COPD combined with respiratory failure; PIC window appears after invasive ventilation and anti-infection treatment (item 1); 3. Diagnosed as AECOPD; and arterial blood gas PH 7.25-7.35, PaCO2> 50 mmHg (item 2); 4. Diagnosed as AECOPD, and arterial blood gas PH 7.20-7.24, PaCO2> 50 mmHg (item 3).
Exclusion criteria
Exclusion criteria: 1. Those who need emergency tracheal intubation; 2. Unable to obtain informed consent; 3. Those who have NIV contraindications: oral and facial trauma, poor sputum excretion ability, unstable hemodynamics, etc.; 4. Those with a poor short-term prognosis and those with a high risk of death within 7 days are undergoing palliative treatment; 5. Severe heart, brain, liver, and kidney organ failure; 6. When the PIC window appears, the cough reflex is extremely weak or the expectoration is weak (item 1); 7. Those with pneumothorax, hemoptysis, and severe pneumonia; 8. Those who cannot obtain informed consent.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Comfort score;Dyspnea score;Changes of diaphragm function;Length of stay;28 day mortality; | — |
Primary
| Measure | Time frame |
|---|---|
| Arterial blood gas;Respiratory rate;heart rate;blood pressure; | — |
Countries
China
Contacts
Public ContactDingyu Tan
Northern Jiangsu People's Hospital
Outcome results
None listed