Yolk sac tumor
Conditions
Interventions
Case series:Sirolimus +TIC chemotherapy regimen
Sponsors
Shandong Cancer Hospital and Institute
Eligibility
Sex/Gender
All
Age
No minimum to 14 Years
Inclusion criteria
Inclusion criteria: (1) The child must have histological evidence of extracranial malignant germ cell tumor (yolk sac tumor); (2) When participating in the study, the age of children must be no more than 14 years old; (3) Children must have drug resistance after at least two platinum-based chemotherapy regiments or relapse within 3 months after chemotherapy; (4) The child must have a measurable lesion (recorded according to RECIST criteria) or an unevaluable disease with a tumor marker AFP >=5 ULN; (5) Lansky performance status score >=50; (6) The child's life expectancy must exceed 6 weeks; (7) The child must have recovered from all previous responses to anticancer therapy; (8) no serious organ dysfunction: normal cardiac function (cardiac ejection fraction > 50% or BNP < 2000pg/ml); Liver function: alANINE aminotransferase in the upper limit of the normal value of 5 times below, bilirubin in the upper limit of the normal value of 3 times below; Renal function: creatinine, urea nitrogen levels below the normal range; White blood cells and platelets were greater than 3x10^9/L and 100x10^9/L respectively; (9) Obtain and sign an informed consent form from the guardian.
Exclusion criteria
Exclusion criteria: (1) Patients with other tumors; (2) Patients with heart, brain, liver, kidney and other organ failure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The sum of the longest diameters of all target lesions; | — |
Countries
China
Contacts
Public ContactWang Jingfu
Shandong Cancer Hospital and Institute
Outcome results
None listed