digestive tract disease
Conditions
Interventions
Group 2:propofol
Group 1:remazolam
Sponsors
The Central Hospital of Enshi Tujia and Miao Autonomous Prefesture
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 65 years old; 2. Patients undergoing elective painless gastrointestinal endoscopy; 3. ASA I/II; 4. No serious cardiovascular and cerebrovascular diseases, normal liver and kidney function, no history of anesthetic allergy and other special medical conditions. Patients with any of the following exclusion criteria cannot be included in this study; 5. Patients or their family members have a full understanding of the purpose and significance of this trial, volunteer to participate in this clinical trial, and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. The patient's physical condition is difficult to evaluate (e.g. severe central nervous system surgery or intracranial surgery); 2. Diabetics with unsatisfactory blood sugar control (11.1mmol/L >=during screening period ); 3. A history of myocardial infarction and unstable angina within 6 months of the screening period; 4. Patients with titration (heart rate 1.5 ULN, APTT >1.5 ULN), hemorrhage tendency (e.g. active peptic ulcers) or receiving thrombolytic or anticoagulant therapy; 8. Abnormal liver function, ALT and/or AST> 1.5 ULN; 9. Abnormal renal function, blood creatinine (Cr) and/or urea nitrogen (BUN) >1.5 ULN; 10. Allergic to the ingredients or components of the drug under test; 11. Pregnant or lactating; 12. Participate in clinical trials of other drugs within 3; 13. Patients with severe muscle weakness, schizophrenia, and severe depression; 14. Patients who are allergic to benzodiazepines.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood pressure;Oxygen saturation;Chung’s score; | — |
Secondary
| Measure | Time frame |
|---|---|
| MOAA/S;Narcotrend;Intleter tolerance score;Anaesthetic wakes up; | — |
Countries
China
Contacts
Public ContactZhu Xianlin
The central hospital of Enshi tujia and miao autonomous prefesture
Outcome results
None listed