Laparoscopic bariatric surgery
Conditions
Interventions
Group S1:Esketamine loading dose:0.15mg/kg IV
Group S2:Esketamine loading dose:0.25mg/kg IV
Group S3:Esketamine loading dose:0.35mg/kg IV
Sponsors
The First Affiliated Hospital of Jinan University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 60 years; 2. ASA I-III grade; 3. BMI greater or equal to 28 kg/m2; 4. Patients undergoing laparoscopic bariatric surgery; 5. The patient or family member fully understood the purpose and significance of this experiment, volunteered to participate in this clinical trial, and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients undergoing bariatric surgery not for the first time; 2. Severe cardiovascular, kidney, and liver diseases; 3. With mental illness and cannot cooperate; 4. Have taken antidepressants or other interventions in the past 4 weeks; 5. Blood pressure greater than or equal to 180/100mmHg; untreated or poorly hypertension control; 6. Intracranial hypertension; 7. Glaucoma; 8. Untreated or inadequately treated hyperthyroid; 9. There was a history of bradycardia; 10. Alcohol abuse and alcoholism; 11. Patients who are allergic to the drugs used in this study; 12. The investigators determined that the patients were not eligible for other conditions in the clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NRS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic changes;Propofol and remifentanil consumption;Extubation time;Postoperative intestinal exhaust time;Postoperative ays of hospitalization;PHQ-9, CAD-7;PONV;Respiratory depression;Wakening delay;EA; | — |
Countries
China
Contacts
Public ContactYalan Li
The First Affiliated Hospital of Jinan University
Outcome results
None listed