Degenerative Lumbar Spondylolisthesis
Conditions
Interventions
posterior lumbar interbody fusion group:posterior lumbar interbody fusion
transforaminal lumbar interbody fusion group:transforaminal lumbar interbody fusion
minimally invasive surgery-transforaminal lumbar interbody fusion group:minimally invasive surgery-transforaminal lumbar interbody fusion
Sponsors
Department of Spinal Orthopaedics, The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged from 40 to 80 years; 2. The patients with single-segment lumbar degenerative disease had corresponding manifestations of spinal canal stenosis or spondylolisthesis, including lumbar pain, radiation pain, intermittent claudication, sensory abnormality, motor dysfunction and reflex abnormality; 3. With conservative treatment ineffective for more than 3 months; 4. Imaging showed stenosis of spinal canal and spondylolisthesis of lumbar vertebrae I - II degree; 5. The clinical symptoms and signs are consistent with the imaging findings; 6. The severity of the disease reached the standard of surgical treatment; 7. No history of lumbar trauma or surgery.
Exclusion criteria
Exclusion criteria: 1. There are degenerative lesions in multiple lumbar segments; 2. Lumbar spinal stenosis caused by other spinal diseases, such as ankylosing spondylitis and spinal tumors; 3. Complicated with other spinal diseases, such as spinal tumors, spinal infections, spinal deformities, etc.' 4. There are other lesions that may cause low back pain and lower limb dysfunction, such as burst fracture of vertebral body, intermittent claudication caused by arterial embolism of lower extremities, cerebrovascular accident, etc.; 5. Serious medical diseases and metabolic diseases such as severe cardiopulmonary insufficiency or severe osteoporosis; 6. Severe osteoarthritis or rheumatoid arthritis, resulting in joint dysfunction of the lower extremities; 7. Neurological or mental disorders, such as dementia, stroke, etc., in which informed consent cannot be given; 8. After total hip or knee arthroplasty; 9. There are recent muscle injury and its possibility.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oswestry Disability Index;Japanese Orthopaedic Association Scores;Visual analogue scale of low back pain;Visual analogue scale of lower extremity pain;The height of the intervertebral space at the lesion segment;creatine kinase(CK);Cross-sectional area of paraspinal muscle;Fat infiltration of paraspinal muscle;Hyperemia degree of paraspinal muscle; | — |
Countries
China
Contacts
Public ContactJiang Xiaobing
Guangzhou University of Chinese Medicine
Outcome results
None listed