sepsis
Conditions
Interventions
Gold Standard:1.Clinical diagnostic criteria for sepsis: infection, with changes in SOFA score >=2 points.
2.Clinical diagnostic criteria for septic shock: on the basis of definite diagnosis of sepsis
ultrasound 
of 
area.
molecular 
markers 
to 
resuscitation 
in 
patients
Sponsors
Shanghai Tenth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >18 years; 2. Critically ill patients diagnosed with septic shock and require PICCO to monitor hemodynamics. Septic shock was diagnosed according to the international guidelines for sepsis and septic shock in 2016; 3. There is enough time for bedside ultrasound monitoring, PICCO monitoring and exploration of capacity-related molecular biological markers.
Exclusion criteria
Exclusion criteria: 1. Patients with PICCO catheterization contrains, such as poor arterial conditions, arterial plaques, venous thrombosis, coagulation dysfunction, local infection in the puncture area, etc.; 2. Bedside ultrasound examination is difficult to obtain clear and stable images of patients, such as chest injury, deformity, inferior vena cava unclear display, etc.; 3. Patients with arrhythmia, such as atrial fibrillation, frequent contraction, etc.; 4. Patients with malignant tumors and intra-abdominal high pressure; 5. Patients with AIDS and severe infectious diseases; 6. Patients during lactation or pregnancy; 7. Patients with terminal malignancy; 8. Refuse to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ITBVI;GEDV;CO;Cross-sectional area of inferior vena cava, Rate of variation in inferior vena cava cross-sectional area; | — |
Secondary
| Measure | Time frame |
|---|---|
| IVCD;Variation rate of inferior vena cava diameter;LVEDV;LVEF;Jugular vein diameter;Variation rate of Jugular vein diameter;Organ Function Index (LDH, CK-MB, TNT; ALB, ALT, ALP, D-BIL, I-BIL, AST, AMY, BA, BUN, Cr; PT, INR, APTT, Fib, D-D, FDP; CRP, WBC, HB, PLT, N%, L%);Arterial blood gas analysis (PH, Lac);Volume index (NT-pro-BNP, HCT);Infected index(PCT);Vital sign (T, HR, RR, BP, MBP, SpO2, HRV);Volume index (CVP);Intake and output volume (Venous Access volume, Gastrointestinal decompression volume, Wound drainage, Fecal quantity, The amount of EN or TPN, The types of EN or TPN);Vasoactive drug (types, amount);CIS (APACHE II score (include GCS score), SOFA score, MODS score);Clinostatism (Renin, Angiotensin, ADS); | — |
Countries
China
Contacts
Public ContactLiu Yongchao
Shanghai Tenth People's Hospital
Outcome results
None listed