General Anesthesia
Conditions
Interventions
one:oxycodone hydrochloride 5mg
two:same dose of normal saline
Sponsors
Wuxi 9th Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Aged 18 to 65 years old; 2) Perform elective surgery (for tracheal intubation and mechanical ventilation); 3) ASA score is II-III level; 4) BMI 30 kg/m2 to 40kg/m2; 5) Clearly understand and voluntarily participate in the research, and the informed consent form should be signed.
Exclusion criteria
Exclusion criteria: 1) Emergency surgery; hypovolemia, shock or coma; 2) In addition to general intravenous anesthesia, other anesthesia methods, such as inhalation anesthesia, rigid extra-membrane and subarachnoid anesthesia, etc.; 3) Infectious heart diseases such as myocarditis or endocarditis; sepsis; 4) Uncontrolled hypertension, diabetes, heart failure, etc.; 5) Abnormal liver function, AST and/or ALT>=2.5 ULN, TBIL>=1.5 ULN; 6) Abnormal renal function, urea or urea nitrogen >=1.5 ULN, and blood creatinine greater than the upper limit of normal; 7) Suffer from mental system diseases (schizophrenia, mania, bipolar disorder, mental disorder Etc.) and those with long-term history of taking psychotropic drugs and cognitive impairment; 8) Women who are pregnant or breastfeeding; 9) Those who are allergic or contraindicated to benzodiazepines, opioids, propofol, muscle relaxants and other drugs and their drug components; 10) Other situations where the researcher thinks it is inappropriate to participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood pressure;heart rate;recovery time;epinephrine, norepinephrine;the cough; | — |
Secondary
| Measure | Time frame |
|---|---|
| sedation scores; | — |
Countries
China
Contacts
Public ContactZhenqing Liu
Wuxi 9th Affiliated Hospital of Soochow University
Outcome results
None listed