Septic shock
Conditions
Interventions
Terlipressin combination:After adequated fluid resuscitation, if the dosage of norepinephrine exceeds 10ug/min, add terlipressin, terlipressin (1mg) was dissolved in a 50-mL syringe containing 5% dext
norepinephrine :After adequate fluid resuscitation, only norepinephrine was used to maintain the target blood pressure
Sponsors
Jiangsu Provincial Hospital on Integrated Traditional Chinese and Western Medicine
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Patients older than 18 years diagnosed with septic shock. Septic shock was defined: proven or suspected infection, and hypotension despite adequate fluid resuscitation (sepsis induced hypotension defined as systolic blood pressure (SBP)40 mmHg below normal for age in the absence of other causes of hypotension). After adequate fluid resuscitation, to maintain blood pressure, the dosage of norepinephrine exceeds 10ug/min.
Exclusion criteria
Exclusion criteria: (1) unstable coronary syndrome (acute myocardial infarction during this episode of shock based on the combination of history, electrocardiogram and enzyme changes; (2) previous use of terlipressin for arterial blood pressure support during the current ICU admission; (3) malignancy or other irreversible disease or condition for which mortality was estimated to be very high (defned by investigator); (4) acute mesenteric ischaemia either proven or suspected; (5) Raynauds phenomenon; (6) pregnancy; (7) organ transplantation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to target mean arterial pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| SOFA;Urine output;Cumulative drug dose; | — |
Countries
China
Contacts
Public ContactHaibin Ni
Jiangsu Provincial Hospital on Integrated Traditional Chinese and Western Medicine
Outcome results
None listed