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Study on the efficacy of intravenous injection of granisetron before induction to reduce ephedrine in preventing hypotension ED50 in elderly patients after induction of general anesthesia

Study on the efficacy of intravenous injection of granisetron before induction to reduce ephedrine in preventing hypotension ED50 in elderly patients after induction of general anesthesia

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000040344
Enrollment
Unknown
Registered
2020-11-28
Start date
2020-12-01
Completion date
Unknown
Last updated
2021-02-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

(Hypotension after induction of general anesthesia,GAIH)

Interventions

Experimental group:Intravenous injection of Glasgow before induction of general anesthesia
Control group:Intravenous injection of the same amount of normal saline before induction of general anesthesia

Sponsors

Run Run Shaw Hospital affiliated to Medical College of Zhejiang University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 74 Years

Inclusion criteria

Inclusion criteria: 1. elderly patients with ASA I or II; 2. aged between 60 and 74 (this stage is defined by WHO as young old people); 3. BMI 18.5 to 23.9 (according to the Chinese standard); 4. non-cardiac endotracheal intubation general anesthesia was planned.

Exclusion criteria

Exclusion criteria: 1. History of cardiovascular and cerebrovascular diseases; 2. istory of arrhythmia (including bradycardia and tachycardia); 3. history of respiratory diseases; 4. hypotension (noninvasive mean pressure < 70mmHg) or hypertension; 5. hyperthyroidism; 6. patients with hepatic and renal insufficiency; 7. the patients with hyperglycemia are not treated or the therapeutic effect is not good; 8. people with self-reported allergies to eggs or soybeans; people with gastrointestinal obstruction or allergies to granisetron or related compounds; 9. patients with prostatic hypertrophy; 10. patients who refuse or are unwilling to sign the informed consent form.

Design outcomes

Primary

MeasureTime frame
Noninvasive blood pressure;

Countries

CHINA

Contacts

Public ContactChen Gang

Run Run Shaw Hospital affiliated to Medical College of Zhejiang University

chengang120@hotmail.com+86 13757118681

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026