total abdominal hysterectomy
Conditions
Interventions
TAP group:Ultrasound-guided Transversus Abdominis Plane Block 0.375% ropivacaine 40ml
Dexamethasone 5mg and Kepens 50mg before peeling
2. 6h after surgery, Kefen 60mg, 1-2d after surgery: PCA morphine, oral acetaminophen 650mgtid, Celebrex 200mgbid.
Control group:1. Dexamethasone 5mg and Kepens 50mg before peeling
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Female patients aged 18-65 years old with American Society of Anaesthesiologists (ASA) physical status I-II, scheduled for elective open gynecological surgery under general anaesthesia were assessed for eligibility.
Exclusion criteria
Exclusion criteria: (1) ASA physical status III or more; (2) pre-existing significant hepatic (liver enzymes more than two times normal values) or renal disease (estimated glomerular filtration rate <60 mL/min/1.73m2); (3) chronic diseases requiring regular corticosteroid or opioid treatment; (4) known allergy or contraindication to any of the drugs used in the study; (5) previous history of peptic ulcer, gastrointestinal bleeding or perforation; (6) inability to communicate due to psychiatric or nervous system diseases; (7) pregnant or breasting; (8) refuse to participate the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain; | — |
Contacts
Public ContactZhiYu Geng
Department of Anesthesiology, Peking University First Hospital
Outcome results
None listed