Osteoarthritis
Conditions
Interventions
control group:Conventional infusion scheme
Experimental group:Low dose norepinephrine pump injection
Sponsors
Fujian Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) According to the clinical diagnostic criteria in the guidelines for the diagnosis and treatment of osteoarthritis formulated by the Chinese Medical Association in 2010, and underwent unilateral total knee arthroplasty for the first time; (2) the coagulation function was normal in the preoperative blood routine examination; (3) Stable vital signs and good blood circulation function; (4) the total amount of fluid infusion in 24 hours was not more than 2000 ml.
Exclusion criteria
Exclusion criteria: (1) Patients with hemorrhagic diseases; (2) patients with long-term anticoagulant therapy or history of thrombotic diseases; (3) patients with anemia; (4) patients with allergy to research drugs; (5) patients with heart disease and liver disease; (6) other absolute and relative contraindications of surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Red blood cell count;Hemoglobin concentration;Reticulocyte count;Prothrombin time;Mean arterial pressure;Heart rate;Arterial blood lactate concentration;Intraoperative blood loss;Postoperative complications;Blood loss on osteotomy surface;Intraoperative fluid volume;Average length of stay; | — |
Countries
China
Contacts
Public ContactChen Shijie
Fujian Provincial Hospital
Outcome results
None listed