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Clinical study of pediatric sodium-taurocholate cotransporting polypeptide deficiency patients

Clinical features of sodium-taurocholate cotransporting polypeptide deficiency in pediatric patients: case series and literature review

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000040305
Enrollment
Unknown
Registered
2020-11-27
Start date
2020-11-18
Completion date
Unknown
Last updated
2021-02-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sodium-taurocholate cotransporting polypeptide deficiency

Interventions

Case series:None

Sponsors

West China Second University Hospital of Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
0.1 Years to 5 Years

Inclusion criteria

Inclusion criteria: The age is less than 18 years old. Patients presented with hypercholanemia. Gene sequencing revealed homozygous or compound heterzygoous mutations of SLC10A1.

Exclusion criteria

Exclusion criteria: The age is older than 18 years old. Patients presented with deformity of biliary duct. Patients presented with infectious cholestasis. Patients presented with immnunological cholestasis.

Design outcomes

Primary

MeasureTime frame
total bile acid;bilirubin;alanine aminotransferase;aspartate aminotransferase;albumin;vitamin D;blood ammonia;gene results of next generation sequencing;—

Countries

China

Contacts

Public ContactWan Chaomin

West China Second University Hospital

wcm0220@sina.com+86 18180609107

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026