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Study on the relationship between the methylation of the promoter region of the drug transporter ABCB1 gene and paclitaxel induced neutropenia

Study on the relationship between the methylation of the promoter region of the drug transporter ABCB1 gene and paclitaxel induced neutropenia

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000040300
Enrollment
Unknown
Registered
2020-11-27
Start date
2021-01-01
Completion date
Unknown
Last updated
2021-02-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Cancer

Interventions

Case series:none

Sponsors

Cancer Hospital, Chinese Academy of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Aged over 18 years old; ECOG score < 2; With adequate hematopoietic function with absolute neutrophils counts higher than 1.5*10^9/L and platelet counts higher than 100*10^9/L; With adequate hepatic and renal function with alanine transaminase (ALT), aspartate aminotransferase (AST)less than 2.5 folds of upper limit values; Without taking hepatic metabolism enzyme inducer or inhibitor within four weeks; Complete two cycles of chemotherapy; complete medical records

Exclusion criteria

Exclusion criteria: Do not follow the established regimen of chemotherapy or change treatment; Two cycles of treatment were not completed; incomplete medical records; Samples preserved with anticoagulants other than EDTA.

Design outcomes

Primary

MeasureTime frame
Toxicity;—

Countries

China

Contacts

Public ContactHaiyan Zhou

Cancer Hospital, Chinese Academy of Medical Sciences

haiyan917@163.com+86 13522599245

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026