Sepsis
Conditions
Interventions
Sponsors
Zhongshan Hospital Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Healthy control group: (1) Aged 18 to 65 years old; (2) No chronic underlying diseases; (3) There is no infectious disease this time; (4) Obtain informed consent and sign informed consent; 2. Sepsis group: (1) Aged 18 to 65 years old; (2) Sepsis patients who meet the Criteria of Sepsis 3.0 according to the 2016 international Sepsis expert consensus, namely, for patients with infection or suspected infection, when the Sepsis related sequential organ failure SOFA score increases by >=2 points from baseline; (3) The septic shock standard was not reached according to Sepsis 3.0 standard; (4) Obtain informed consent and sign informed consent; 3. Septic shock group (1) Aged 18 to 65 years old; (2) Sepsis patients who meet the Criteria of Sepsis 3.0 proposed by the 2016 international Sepsis expert consensus, that is, for patients with infection or suspected infection, when the Sepsis related sequential organ failure SOFA score increases by >=2 points from baseline; (3) Meet the septic shock standard according to Sepsis3.0 standard: in the case of appropriate fluid replenishment still need to use the booster treatment to maintain MAP>=65mmHg; Patients with septic shock with blood lactic acid level of >2mmol/L; (4) Obtain informed consent and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. patients with congenital immune deficiency, tumor, rheumatic immune system disease, blood system disease, hormone or immunomodulatory drugs within 1 month after organ transplantation; 2. Patients suffering from uncontrollable neurological, mental illness or mental disorder, poor compliance and inability to cooperate; 3. patients who have joined other clinical trials; 4. Circumstances that the researcher considers inappropriate for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SOFA score; | — |
Secondary
| Measure | Time frame |
|---|---|
| APACHE II score;PSI score; | — |
Countries
China
Contacts
Public ContactWU DUOJIAO
Zhongshan Hospital Fudan University
Outcome results
None listed