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Effects of intermittent theta pulse stimulation on auditory evoked potential P300 and brain electrical activity in type 2 diabetes mellitus with mild cognitive impairment

Effects of intermittent theta pulse stimulation on auditory evoked potential P300 and brain electrical activity in type 2 diabetes mellitus with mild cognitive impairment

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000040294
Enrollment
Unknown
Registered
2020-11-27
Start date
2020-11-23
Completion date
Unknown
Last updated
2021-02-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes with mild cognitive impairment

Interventions

Really stimulate group:Intermittent theta pulse stimulation
Sham stimulation group:Sham intermittent theta pulse stimulation

Sponsors

Department of Rehabilitation Medicine, Shenzhen Baoan District People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Type 2 diabetes patients with mild cognitive impairment (MCI); 2. Aged 60 to 75 years; 3. Eyesight and hearing can complete the clinical test; 4. Right-handedness; 5. Sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. Neuropsychosis and other medical or neuropsychological conditions such as alcohol and/or substance abuse that can cause brain dysfunction; 2. Complicated with cardiovascular, cerebrovascular, liver, kidney and hematopoietic system and other serious primary diseases; 3. There are contraindications for TMS treatment: pacemaker or cochlear implant, implant device (e.g. Deep brain stimulator, ventriculoperitoneal shunt) or metal in the brain (e.g. Aneurysm clip); 4. Taking cognition-related drugs and participating in other similar research projects; 5. Patients with epilepsy or epilepsy family; Hypothyroidism, a history of mental illness or a combination of other conditions that may affect cognitive function.

Design outcomes

Primary

MeasureTime frame
Auditory evoked potential P300 incubation period;Amplitude of auditory evoked potential P300;frequency spectrum;

Countries

China

Contacts

Public ContactWang Dan

Department of Rehabilitation Medicine, Baoan District People's Hospital

1060433850@qq.com+86 18682118750

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026