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Colorectal cancer organoid model predicts the effect of (neo) adjuvant therapy in cancer patients

Based on the colorectal cancer organoid model to predict the effect of neoadjuvant and adjuvant treatment for tumor patients

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000040287
Enrollment
Unknown
Registered
2020-11-27
Start date
2020-12-01
Completion date
Unknown
Last updated
2021-02-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal cancer

Interventions

Group 1:neoadjuvant treatment
Group 2:adjuvant treatment

Sponsors

Shanghai Jiaotong University School of Medicine of Ruijin Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 years to 80 years old; 2. Pathological type is adenocarcinoma; 3. The tumor was located at the junction of colorectal; 4. Preoperative imaging examination of thoracic, abdominal and pelvic plain scan CT, and/or rectal MR to assess tumor staging, patients who are scheduled to undergo neoadjuvant treatment before surgery through MDT; patients with advanced colorectal cancer who need adjuvant treatment after postoperative pathology.

Exclusion criteria

Exclusion criteria: 1. Multiple primary tumors; 2. The preoperative radiological staging T1N0M0; 3. Patients who had a history of malignancy elsewhere; 4. Patients undergoing emergency surgery; 5. Patients not suitable for surgery (the underlying disease is severely intolerant of surgery; patients with advanced rectal cancer do not meet the indications for surgery, etc.); 6. The researchers determined not suitable to participate in the study.

Design outcomes

Primary

MeasureTime frame
Imaging results (CT and/or MR);Tumor regression (TRG stage);PDO quantity and size;

Countries

China

Contacts

Public ContactLU AIGUO

Shanghai Jiaotong University School of Medicine of Ruijin Hospital

adams_lu66@163.com+86 13611971658

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026