Breast cancer
Conditions
Interventions
Minocycline group:Minocycline
Thoracic paravertebral nerve block:Thoracic paravertebral nerve block
Minocycline combined with thoracic paravertebral nerve block group:Minocycline combined with thoracic paravertebral nerve block
Sponsors
He'nan Provincial People's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1) Women with breast cancer aged 18-70 years; 2) Breast cancer patients undergoing elective total mastectomy; 3) American Association of Anesthesiologists (ASA) classification I-II; 4) Agree to join the experimental research.
Exclusion criteria
Exclusion criteria: 1) Allergic to minocycline; 2) History of spinal cord injury; 3) There has been chronic neuropathic pain caused by other reasons (such as: diabetes, alcohol or drugs); 4) Depression or other reasons that affect pain judgment or cannot cooperate with research; 5) Take antidepressants; 6) Pregnant women or patients with recent pregnancy requirements; 7) Thoracic paravertebral nerve block cannot be performed due to various reasons; 8) Abnormal liver and kidney function; 9) Participating in other clinical research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS scores of patients;DN4 table;Lipidomics; | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory factors; | — |
Countries
China
Contacts
Public ContactJie Wang
Zhengzhou University People's hospital (He'nan Provincial People's Hospital)
Outcome results
None listed