osteoporosis and sarcopenia
Conditions
Interventions
Sponsors
Zhongshan Hospital affiliated Fudan University
Eligibility
Sex/Gender
All
Age
65 Years to 105 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria of cross-sectional investigation: (1) Aged >=65 years; (3) Volunteer to participate in this study and sign the informed consent. 2. Inclusion criteria for the randomized controlled study: (1) Aged >=65 years; (2) No previous or current usage of oral vitamin D, glucocorticoid and other drugs which affect blood VitD level; (3)reduced bone mass or reduced skeletal muscle mass confirmed by DXA; (4) serum 25(OH) Vit D < 50ng/l; (5) Volunteer to participate in this study and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) already participated in other drug clinical trials; (2) unable to complete grip strength assessment and scale survey; (3) abnormal spirits; (4) severe liver or renal insufficiency, acute stage of chronic diseases, patients with malignant tumors and other major diseases whose expected survival time is less than 1 year; (5) In the acute and critical stage of acute infection, cardiovascular and cerebrovascular events and other diseases (6) use drugs that affect body components, such as vitamin D, bisphosphonates and glucocorticoids; (7) Hypercalcemia; (8) Patients requires a low-protein diet; (9) Refuse to participate in the clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| skeletal muscle mass;grip strength;bone mineral density;fracture; | — |
Secondary
| Measure | Time frame |
|---|---|
| Frail Scale; | — |
Countries
China
Contacts
Public ContactHu Yu
Zhongshan Hospital affiliated to Fudan University
Outcome results
None listed