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A nested case-control study on the changes of bile composition and its effect on postoperative complications in patients with malignant obstructive jaundice after preoperative biliary drainage

A nested case-control study on the changes of bile composition and its effect on postoperative complications in patients with malignant obstructive jaundice after preoperative biliary drainage

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000040277
Enrollment
Unknown
Registered
2020-11-27
Start date
2020-12-01
Completion date
Unknown
Last updated
2021-03-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malignant obstructive jaundice

Interventions

4weeks group: Time intervention

Sponsors

The General Hospital of Western Theater Command PLA
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: (1) patients aged 18-75 years old; (2) patients with obstructive jaundice symptoms (skin yellow staining, sclera yellow staining, deep yellow urine, etc.), serum total bilirubin > 250 umol/L); (3) preoperative imaging examination and clinical diagnosis considered malignant obstruction (gallbladder carcinoma, hilar cholangiocarcinoma, pancreatic head cancer, lower common bile duct cancer, ampullary cancer, duodenal cancer, etc.); (4) patients and their families informed consent and voluntary participation.

Exclusion criteria

Exclusion criteria: (1) those who have surgical contraindications or cannot receive surgical treatment for various reasons; (2) those with biliary obstruction caused by various benign diseases (stones, etc.); (3) those who only receive palliative surgery; (4) those who cannot complete regular follow-up.

Design outcomes

Primary

MeasureTime frame
Bile acid;Incidence of complications;bilirubin;cholesterol;phospholipids;

Countries

China

Contacts

Public ContactDai Ruiwu

The General Hospital of Western Theater Command PLA

rwdai@163.com+86 15228267646

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026