Knee anterior cruciate ligament injury
Conditions
Interventions
PRP group:PRP injection 4w, 8w & 12w after surgery
Control group:No postoperative PRP injection
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
16 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Patients with ACL injury confirmed by imaging and knee arthroscopy who are scheduled to undergo ACLR; 2. Aged 16-45 years old, femoral and tibial epiphyses are closed; 3. The range of motion of the knee joint is basically restored before the operation (reach nearly full extension and bent over 120 degree); 4. Volunteer to participate in the research and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Multiple ligament injuries caused by severe trauma (combined with posterior cruciate ligament injury, posterolateral structural injury, medial patellofemoral ligament injury, and medial collateral ligament injury of degree II or higher); 2. Bilateral ACL injury or contralateral knee dysfunction; 3. Combined with tibial plateau fracture, severe cartilage damage, meniscus repair, and osteoarthritis; 4. Past surgery history of the knee joint (ipsilateral and contralateral); 5. Combined with other system diseases, such as malignant tumors, blood system, rheumatism and endocrine and metabolic diseases; 6. History of infectious diseases transmitted through blood, such as HIV, HBV, HCV, syphilis infection, etc.; 7. Children under 16 years old, pregnant and lactating women; 8. History of drug and alcohol abuse, cognitive dysfunction and history of mental illness; 9. Other situations that cannot cooperate with postoperative medication and rehabilitation and completion of follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| KOOS4 (symptoms, pain, sports and recreation, quality of life); | — |
Secondary
| Measure | Time frame |
|---|---|
| GROC (-7~+7);KOOS (5 subscales);Knee ROM;Knee circumference;MRI indicators (i.e. SNQ);P4 (VAS at 4 timepoints);PROs (Tegner, Lysholm, IKDC scores);Objective tests (ADT, Lachman, PST, KT-1000); | — |
Countries
China
Contacts
Public ContactZhao Jinzhong
Shanghai Sixth People's Hospital
Outcome results
None listed