clock rhythm
Conditions
Interventions
T1:The starting time of operation was 8am-14pm
T2:The starting time of operation was 14pm-20pm
T3:The starting time of operation was 20pm-8am
Sponsors
ZhongShan Hospital Fudan University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Patients suffering luncer who receive VATS surgery; 2) ASA I-II grade; 3) Aged 65-80 years; 4) BMI 18.5-23.9; 5) Voluntarily participate in this clinical trial and sign informed consent.
Exclusion criteria
Exclusion criteria: 1) Patients with severe heart, brain, liver, kidney and other important organ dysfunction patients; 2) Patients with mental disease, neuroendocrine system, immune system disease before surgery; 3) Emergency surgery due to bleeding, anastomotic leakage and other surgical factors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Richmond rating ofter surgery;Richmond rating ofter surgery;Richmond rating ofter surgery;Richmond rating ofter surgery;Richmond rating ofter surgery;Richmond rating ofter surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-6;IL-6;TNF-?;TNF-?;CRP;CRP;PCT;PCT;BMAL1;BMAL1;PER2;PER2;sleepquality;sleepquality;delirium;Plasma melatonin level;Plasma melatonin level;NRS after surgery;NRS after surgery;NRS after surgery;NRS after surgery;NRS after surgery;NRS after surgery; | — |
Countries
China
Contacts
Public ContactXiong Wanxia
ZhongShan Hospital Fudan University
Outcome results
None listed