depression
Conditions
Interventions
Group A:Sports +Venlafaxine Hydrochloride + Oxazepam
Group B:Venlafaxine Hydrochloride + Oxazepam
Sponsors
Tongji Medical College Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-50 years old; 2. Depressed patients who meet the criteria of "Diagnostic and Statistical Manual of Mental Disorders" Fifth Edition (DSM-V) and have no eye diseases; 3. Mild to moderate depression, 21-item Hamilton Depression Scale score 7-24 points; 4. Have not previously received psychotropic drugs or psychotherapy; 5. No aerobic exercise habits (such as brisk walking, jogging, swimming, dancing, biking, etc.), and the total weekly aerobic exercise time is less than 60 minutes; 6. Native Chinese; 7. Sign informed consent.
Exclusion criteria
Exclusion criteria: 1) Suffer from diseases that significantly affect the function of the autonomic nervous system (hyperthyroidism or hypothyroidism, diabetes, obstructive sleep apnea syndrome, etc.); 2) Past history of syncope, family history of sudden cardiac death; 3) Suffering from organic diseases that are not suitable for exercise, such as exercise-related asthma, arthritis, gout, cancer, Crohn's disease, fractures, and heart diseases (including coronary heart disease, hypertrophic cardiomyopathy, arrhythmia and heart failure, etc.); 4) Suffered from other mental illnesses (such as schizophrenia, bipolar disorder, anxiety disorder, suicidal tendency or depression with psychotic symptoms, alcohol and illegal drug abuse, etc.) in the past or at the first visit; 5) Taking drugs that significantly affect the function of the autonomic nervous system (such as beta blockers); 6) There are clear contraindications to SSRIs or benzodiazepines; 7) Cannot continue moderate-intensity exercise for more than 40 minutes; 8) Correcting vision or hearing affects sports safety; 9) Are participating in clinical research projects related to sports or weight management; 10) Female patients who are pregnant, breastfeeding, or have a pregnancy plan in the next 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Remission rate of depression;Autonomic dysfunction improvement rate; | — |
Countries
China
Contacts
Public ContactYuan Yang
Tongji Medical College Huazhong University of Science and Technolog
Outcome results
None listed