Rib fracture
Conditions
Interventions
Esketamine group:Intraoperative and postoperative intravenous administration of Esketamine
Control group:Intraoperative and postoperative intravenous use of Physiological saline
Sponsors
Xiang'an Hospital of Xiamen University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 20-60 years; 2. American Association of Anesthesiologists (ASA) graded from I to III; 3. BMI between 18-26kg/m2; 4. Accepted general anesthesia and postoperative Analgesia; 5. Volunteer to participate and sign the informed consent form for clinical trials.
Exclusion criteria
Exclusion criteria: 1. Allergic to esketamine or general anesthesia drugs; 2. Poorly controlled grade 2 or above hypertension, glaucoma, hyperthyroidism, and intracranial hypertension; 3. Lung infections, chronic obstructive pulmonary disease and others that can cause hypoxemia; 4. Infections or inflammatory diseases; 5. Dependent on narcotic drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean arterial pressure;Heart rate;Pulse oximetry;Respiratory rate;Type and dosage of analgesic drugs;VAS;Richmond Agitation-Sedation Scale;Wong-Baker Faces Pain Rating Scale;White blood cell count;C reactive protein;Tumor necrosis factor alpha;Interleukin-6;Interleukin-8; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative airway pressure;Postoperative dizziness;Postoperative restlessness;Postoperative nausea and vomiting;Postoperative delirium;Frequency of analgesia pump use; | — |
Countries
China
Contacts
Public ContactDeng Bin
Xiang'an Hospital of Xiamen University
Outcome results
None listed